Image source: http://www.medindia.net/images/common/news/950_400/new-promising-treatment-for-menopause.jpg
2. Blackley J., et. Al. Uremic pruritus: skin divalent ion content andresponse to ultraviolet phototherapy. Am J Kidney Dis, Vol V, No 5, May1985.
References:
1. Cross H., Peterlik M. Effects of diet D and insulin on phosphatetransport in the differentiating chick small intestine. Calcium andPhosphate Transport. 1981. Pp. 293-296.
The association believes that HPD3 relieves itch in the same way thatultraviolet light therapy does. Ultraviolet light therapy and HPD3 mostlikely work by reducing elevated phosphate levels in itchy skin. Thefollowing is an excerpt from the association website detailing thepathophysiology involved.
3. Martindale: The Extra Pharmacopoeia 30th ed. 1993
A promising new therapy for itch has come to my attention. DermaViveInc, an Oregon association located near my exercise session has introduced a uniqueproduct, DermaVive Natural Itch Relief Cream. The product contains 0.1%Menthol, an FDA approved itch ingredient plus HPD3, High Potency VitaminD3. The founder of the association, Marilyn Strube, discovered the anti-itchproperty of HPD3 while suffering from a severe case of chickenpox. Sheused her background as a medical research biologist to determine themechanism of action. In doing so, she unraveled a medical mystery.Ultraviolet B (UVB) light therapy is highly effective at relieving itch,but researchers failed to understand why. A rich quantity of vitaminD3 is formed in skin in the course of exposure to sunlight, but since diet D3formulations on a regular basis fail to relieve itch, diet D3 was notimplicated. Strube's research determined that to achieve ananti-pruritic (itch) influence in a topical therapy, a relatively highconcentration of diet D3 is required, along with a formulation thatpromotes sufficient absorption.
Summary:
"Vitamin D is formed in skin in the course of exposure to sunlight. The sun'senergy, specifically ultraviolet (UV) light, causes diet D to beformed from its precursor, 7-dehydrocholesterol (3).
A Promising New Therapy for Itch
The depletion of diet D may happen in skin damaged by disease, burns,wounds, viral infections and aging. A number of conditions have beenproven to be associated with the two severe itch and diet depletion.These conditions include kidney failure, liver cirrhosis, chickenpox,HIV infection and aging (four,5,6). Replenishing the diet D topically isthe most direct, effective and natural method of reversing themechanisms that lead to itch."
A study reported in the American Journal of Kidney Disease (2)demonstrated that the skin cells of patients suffering with severe itchcontained abnormally high concentrations of phosphate ions. Aftertreatment with ultraviolet light, the focus of phosphate ionswas reduced to strange levels in 8 of 9 patients, along with acorresponding reduction in itch. Molecules made partially of phosphateions, such as magnesium phosphate, are on a regular basis dissolved in the fluidinside the skin cells. The study authors believed that at abnormallyhigh concentrations, these molecules precipitate, resulting inirritation of nerve endings manifested as itch. If the phosphate isreduced, the molecules dissolve back into answer with a resultingdecrease in itch. Because diet D is a principal and potent regulatorof phosphate metabolism (1) and brooding about that it is formed in the skin duringexposure to ultraviolet light, the authors speculated that diet D mayhave a role in the action of UV light therapy for itch.
6. MacLaughlin J. and Holick M. Aging decreases the capacity of humanskin to produce diet D3. J. Clin. Invest. Vol. 76 Oct. 1985. 1536-38.
I'm so impressed with the anti-itch effects of DermaVive Natural ItchRelief Cream, I wish to pass the information on to others who maybenefit from it. I have agreed to act as an independent medical advisorto the association, but otherwise have no affiliations with DermaVive Inc.
Product information and ordering are available at the association website atwww.dermavive.com.
The association is working to gather efficacy data in preparation for aclinical trial. I agreed to give product samples to 30-40 clinicpatients. I asked patients to test the product. Those I askedppatients were asked to evaluate the product and fill out aquestionnaire. Over ninety% of the patients surveyed experienced similar orbetter relief compared to conventional OTC or prescription products.Surveys from two other clinics have yielded similar results.
four. Campos F., Flores H., Underwood B. Effect of an infection on vitaminD status of youngsters as measured by the relative dose response (RDR). AmJ Clin Nutr 1987:46:91-four.
Itch is a particularly distressing symptom for millions of patientssuffering from skin diseases. Severe, chronic itch can significantlyreduce the quality of life and scratching can cause skin damage and leadto infection. Limited enhancements have been made in the past severaldecades in the therapy of itch, so patients are faced with the choiceof continuing to suffer, using palliative OTC products that offer onlyminor relief or and other expensive prescription treatments, such assteroid creams that can damage skin and become less effective over time.
Discussion of an anti-itch therapy that mimics the anti-itch mechanismof UVB light.
